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Abstract #2463

Dual Manganese- and Gadolinium-Enhanced Cardiac MRI Delineates the Peri-Infarct Region in Patients with Severe Ischemic Cardiomyopathy

Rajesh Dash 1 , Yuka Matsuura 1 , Paul J Kim 1 , Hadas Shiran 1 , Phillip Harnish 2 , Michael V McConnell 1,3 , and Phillip C. Yang 1

1 Stanford University, Stanford, CA, United States, 2 Eagle Vision Pharmaceutical Corporation, PA, United States, 3 Engineering, Stanford University, Stanford, CA, United States

Delayed Enhanced MRI (DEMRI) with gadolinium (Gd) has non-specific distribution properties and may overestimate myocardial infarct size. Conversely, Manganese (Mn2+) uptake into live, active cells via L-type Ca2+ channels is specific for live cardiomyocytes. From earlier work with animal MI models in our lab, Manganese-Enhanced MRI (MEMRI) has demonstrated its utility in identifying viable myocardium. We performed dual-contrast DEMRI-MEMRI in humans with ischemic cardiomyopathy. MEMRI infarct volumes were significantly lower than DEMRI, similar to findings in small and large animal models. MEMRI complements DEMRI to accurately delineate the peri-infarct region and viable myocardium in patients with ischemic heart disease.

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