Meeting Banner
Abstract #2457

Detection and Validation of Localized Chronic Iron Deposition within Non-Reperfused Myocardial Infarctions

Avinash Kali 1,2 , Ivan Cokic 1 , Hsin-Jung Yang 1,2 , Richard Tang 1 , and Rohan Dharmakumar 1,3

1 Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Bioengineering, University of California, Los Angeles, CA, United States, 3 Department of Medicine, University of California, Los Angeles, CA, United States

We investigated whether stagnant blood within permanently occluded vasculature in non-reperfused myocardial infarction (MI) could lead to chronic iron deposition within MI territories. T2* maps and Late Gadolinium Enhancement images were acquired from canines subjected to permanent ligation of LAD at 7 days and 4 months post-MI. Relative to remote myocardium, 42.6% T2* loss was observed within the MI territories at 7 days post-MI, and 39.1% T2* loss was observed within the MI territories at 4 months post-MI. Mean iron volume was 2.1% of the total LV at 7 days post-MI and 1.9% of the total LV at 4 months post-MI. Chronic iron deposition can occur in non-reperfused MIs.

This abstract and the presentation materials are available to members only; a login is required.

Join Here