Determination of the myocardial extracellular volume using an ultra-fast T1 quantification sequence: implications for differentiation of myocardial damage
Daniel Gensler 1,2 , Philipp Mrchel 2 , Peter M. Jakob 2,3 , and Peter Nordbeck 1
Department of Internal Medicine I -
Cardiology, University Hospital Wrzburg, Wrzburg,
Center Magnetic-Resonance-Bavaria, Wrzburg, Bavaria,
Physics 5, University of Wrzburg, Wrzburg, Bavaria,
Late gadolinium enhanced (LGE) cardiovascular magnetic
resonance (CMR) is the clinical gold-standard for the
visualization of myocardial viability and impairment due
to various diseases such as myocardial infarction.
However, LGE-CMR has only very limited capabilities for
quantitative measurements of slight abnormalities in the
myocardium, or the differentiation between different
myocardial damage. In the current work an ultra-fast
radial T1-mapping sequence was developed and tested for
its potential in quantification of the myocardial
extracellular volume (ECV) in patients with myocardial
infarction. The obtained ECV-maps in this preliminary
subset of patients allowed for a differentiation between
chronic and acute myocardial infarction areas.
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