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Abstract #2442

Ex-Vivo Cardiac Fibre Imaging using Diffusion Tensor MRI and Optical Projection Tomography

Laurence Jackson 1 , Angela d'Esposito 1 , Bernard Siow 1 , Daniel J Stuckey 1 , and Mark F Lythgoe 1

1 Centre for Advanced Biomedical Imaging, University College London, London, London, United Kingdom

A technique is established for imaging myocyte orientation in the myocardium using Diffusion Tensor MRI, from this orientation information it is possible to determine the myofibre architecture of the heart. The aim of this study is to combine this fibre structure information with optical projection tomography data, allowing the distribution of fluorescent labelled molecules to be imaged in 3D. Optical imaging techniques have the ability to quantify gene expression in tissues by their fluorescent response. A proposed use for this multi-modal technique is quantification of the angiogenic factors associated with the myofibre remodelling following myocardial infarction.

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