Abstract #2442
Ex-Vivo Cardiac Fibre Imaging using Diffusion Tensor MRI and Optical Projection Tomography
Laurence Jackson 1 , Angela d'Esposito 1 , Bernard Siow 1 , Daniel J Stuckey 1 , and Mark F Lythgoe 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, London, United
Kingdom
A technique is established for imaging myocyte
orientation in the myocardium using Diffusion Tensor
MRI, from this orientation information it is possible to
determine the myofibre architecture of the heart. The
aim of this study is to combine this fibre structure
information with optical projection tomography data,
allowing the distribution of fluorescent labelled
molecules to be imaged in 3D. Optical imaging techniques
have the ability to quantify gene expression in tissues
by their fluorescent response. A proposed use for this
multi-modal technique is quantification of the
angiogenic factors associated with the myofibre
remodelling following myocardial infarction.
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