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Abstract #2437

Detailing Myocardial Microstructure in the Ex Vivo Rat Heart Using High Isotropic Spatial Resolution Susceptibility Weighted MRI and Quantitative Susceptibility Mapping

Till Huelnhagen 1 , Andreas Pohlmann 1 , Fabian Hezel 1 , Eva Peper 1 , Min-Chi Ku 1 , and Thoralf Niendorf 1,2

1 Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine (MDC), Berlin, Germany, 2 Experimental and Clinical Research Center, a joint cooperation between the Charite Medical Faculty and the Max Delbrueck Center, Berlin, Germany

Myocardial microstructure is pivotal for cardiac function and provides important information about (patho)physiological conditions of the heart. Ex vivo histology and diffusion weighted imaging (DWI) are commonly used to assess myocardial tissue microstructure, but in vivo DWI of the heart remains challenging due to cardiac and respiratory motion. Encouraged by the recent progress in susceptibility weighted MRI we have investigated the feasibility of high resolution quantitative susceptibility mapping (QSM) for assessment of myocardial microstructure in the ex vivo rat heart at 9.4 T. Results suggest that QSM might be a useful tool for examination of myocardial microstructure.

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