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Abstract #2423

Waveguide Magnetic Resonance Elastography of the Left Ventricle in a Pressure Varying Model

Ria Mazumder 1 , Bradley D. Clymer 1 , Richard D. White 2 , Anthony J. Romano 3 , and Arunark Kolipaka 2

1 Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH, United States, 2 Department of Radiology, The Ohio State University, Columbus, OH, United States, 3 Department of The Navy, Naval Research Laboratory, Washington, DC, United States

Myocardial stiffness (MS) is elevated in heart failure with preserved ejection fraction (HFPEF) wherein the ejection fraction (EF) of the left ventricle (LV) stays normal. Hence, current diagnostic tools that measure EF of the LV inhibit diagnosis of HFPEF. Therefore, there is a need to develop a clinical tool to estimate myocardial stiffness in order to characterize the pathophysiological conditions associated with the disease. In this study, we measure myocardial stiffness in a porcine model with varying LV pressure, using waveguide magnetic resonance elastography to estimate anisotropic stiffness of the LV myocardium.

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