Meeting Banner
Abstract #2420

Microvascular obstruction is associated with greater extracellular matrix remodelling in the remote myocardium after infarction: A T1-mapping study

Venkat Ramanan 1 , Mohammad Zia 2 , Idan Roifman 1 , Bradley H Strauss 1 , Kim Connelly 3 , Graham A Wright 1,4 , and Nilesh Ghugre 1,4

1 Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada, 2 Toronto East General Hospital, Toronto, Ontario, Canada, 3 St Michaels Hospital, Toronto, Ontario, Canada, 4 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Prior studies have shown that extracellular matrix alterations can occur both in infarcted and remote myocardium. However, the relationship between the extracellular volume (ECV) measurements and the severity of infarct has not been explored. Here, we investigate the impact of microvascular obstruction (MVO) on ECV alterations using MOLLI based T1-mapping. We scanned patients post-MI at 48 hour and at 3 weeks. We found that for patients with MVO, ECV was higher significantly in both infarcted and remote tissue at 3 weeks. These findings also suggest that early changes in the remote myocardium may potentially be indicative of long-term adverse remodeling post-AMI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here