Abstract #2418
DTI and Quantitative Histological Correlation of Diffuse Fibrosis in Failing Hearts
Osama Abdullah 1 , Stavros G Drakos 2 , Abdallah Kfoury 3 , Joseph Stehlik 3 , Craig H. Selzman 3 , Bruce B Reid 3 , Nikolaos A Diakos 2 , Kim Brunisholz 3 , Divya Ratan Verma 3 , Omar Wever-Pinzon 3 , Craig Myrick 4 , Dean Y Li 2 , and Edward W Hsu 1
1
Bioengineering, University of Utah, Salt
Lake City, UT, United States,
2
Molecular
Medicine Program, University of Utah, UT, United States,
3
UTAH
Cardiac Transplant Program, UT, United States,
4
Intermountain
Donor Services, UT, United States
Myocardial diffuse fibrosis has been linked to
arrhythmias and sudden cardiac death. Although diffusion
tensor imaging (DTI) is increasingly used to
characterize cardiac diseases, quantitative correlation
between DTI scalar metrics and diffuse fibrosis remains
lacking. In this study, DTI parameters obtained on heart
specimens from idiopathic dilated cardiomyopathy
patients and normal donors were correlated to
histological collagen content measurements. Results
indicate that diffuse fibrosis is significantly
correlated with water diffusivity, and inversely
correlated with diffusion anisotropy. Computational
analysis shows that the behaviors of the DTI parameters
are well explained by compartmental exchange between
myocardial and collagenous tissues.
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