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Abstract #2392

Development of an isolated MR-compatible working pig heart setup for structural and functional analysis of cardiac diseases

Fanny Vaillant 1,2 , Julie Magat 1,2 , Jrme Naulin 1,2 , Virginie Loyer 1,2 , Delphine Vieillot 3 , Vronique Arsac 1,2 , Philippe Diolez 1,2 , and Bruno Quesson 1,2

1 IHU LIRYC, Pessac, France, 2 Centre de Recherche Cardio-Thoracique de Bordeaux INSERM U1045, Universit Bordeaux Segalen, France, 3 Universit Bordeaux Segalen, France

Magnetic Resonance (MR) imaging and spectroscopy allow non invasive characterization of cardiac structure, function and metabolism. We developed a new MR-compatible setup of ex vivo blood-perfusion of pig hearts with a working left atrium and ventricle. Using this setup, we succeeded to record parameters currently used in clinic, such as cardiac structure and dynamics. This ex vivo working heart model provides a new powerful tool to investigate cardiac mechanical and electrophysiological functions, structure and metabolism under well controlled conditions, and will be useful for a better understanding of cardiac function regulation and to assess efficiency of new diagnostic methods and therapies.

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