Abstract #2392
Development of an isolated MR-compatible working pig heart setup for structural and functional analysis of cardiac diseases
Fanny Vaillant 1,2 , Julie Magat 1,2 , Jrme Naulin 1,2 , Virginie Loyer 1,2 , Delphine Vieillot 3 , Vronique Arsac 1,2 , Philippe Diolez 1,2 , and Bruno Quesson 1,2
1
IHU LIRYC, Pessac, France,
2
Centre
de Recherche Cardio-Thoracique de Bordeaux INSERM U1045,
Universit Bordeaux Segalen, France,
3
Universit
Bordeaux Segalen, France
Magnetic Resonance (MR) imaging and spectroscopy allow
non invasive characterization of cardiac structure,
function and metabolism. We developed a new MR-compatible
setup of ex vivo blood-perfusion of pig hearts with a
working left atrium and ventricle. Using this setup, we
succeeded to record parameters currently used in clinic,
such as cardiac structure and dynamics. This ex vivo
working heart model provides a new powerful tool to
investigate cardiac mechanical and electrophysiological
functions, structure and metabolism under well
controlled conditions, and will be useful for a better
understanding of cardiac function regulation and to
assess efficiency of new diagnostic methods and
therapies.
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