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Abstract #2374

Assessment of Longitudinal Changes in Contractile Function using DENSE in Patients with Myocardial Infarction

Christie McComb 1,2 , David Carrick 3 , Rosemary Woodward 2,4 , John McClure 2 , Aleksandra Radjenovic 2 , Colin Berry 2,3 , and John Foster 1,2

1 Clinical Physics, NHS Greater Glasgow & Clyde, Glasgow, United Kingdom, 2 BHF Glasgow Cardiovascular Research Centre, Glasgow, United Kingdom, 3 Cardiology, Golden Jubilee National Hospital, Glasgow, United Kingdom, 4 MRI, Golden Jubilee National Hospital, Glasgow, United Kingdom

Myocardial infarction (MI) causes contractile dysfunction in the affected tissue, which can be assessed by using DENSE (Displacement ENcoding with Stimulated Echoes) to quantify myocardial strain. Peak circumferential strain and strain rate were measured in 50 patients within 7 days of MI, and 47 returned for a follow-up scan after 6 months. Recovery of contractile function was observed in infarcted myocardial segments, and also in segments adjacent to infarction. Changes in the mechanical properties of myocardium following MI are complicated, but it appears that a reduction in infarct size at follow-up is associated with a greater recovery in contractile function.

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