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Abstract #2363

Evaluate Myocardial Function for Patient with Marfan Syndrome by Using Phase-Contrast Magnetic Resonance Imaging

Tzu-Yu Chou 1 , Hsin-Hui Chiu 2 , Wen-Yih Isaac Tseng 3 , Marius Menza 4 , Bernd Jung 4 , and Hsu-Hsia Peng 1

1 Department of Biomedical Engineering and Environmental Sciences, Hsinchu, Taiwan, 2 Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan, 3 Center for Optoelectronic Biomedicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 4 Medical Physics, Department of Radiology, University Hospital Freiburg, Freiburg, Germany

Marfan syndrome (MFS) is an inherent mutation of encoding the fibrillin-1 protein. This protein is in charge of forming microfibrils, which is a basic material to build the elastic fibers. In this study, we used dark-blood phase-contrast (PC) MRI to compute myocardial wall motion velocity for MFS patients and age-matched normal controls. MFS patients presented higher systolic pVz values, shorter diastolic TTPz and TTPr and achieved peak diastolic twist velocity in an earlier phase. In conclusion, systolic pVz, diastolic TTPz and TTPr, and twist velocity provide satisfied information to diagnose myocardial function of MFS patients.

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