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Abstract #2333

Transient Permeability/ Perfusion Change during Microbubble-Facilitated Focused Ultrasound Blood-Brain Barrier Opening: A Small-Animal Observation

Wen Yen Chai 1,2 , Po Chun Chu 2 , Yu Chun Lin 1 , Jiun Jie Wang 3 , Yau Yau Wai 1 , and Hao Li Liu 2

1 Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Taiwan, 2 Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan, 3 Department of Medical Image and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan

The purpose of this study is to evaluate perfusion change caused by FUS-BBB opening, and evaluate the correlation with the permeability change. And the result is that permeability increase after BBB opening highly correlates with the cerebral blood volume increase, and independent of the cerebral blood flow. This information provides useful insights in understanding the pharmacodynamic behavior when intending to apply this approach to deliver drugs into the brain.

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