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Abstract #2304

Gravitational Distribution Gradient of Inert Fluorinated Gases in Human Lungs Using 19 F Ultra-Short Echo Time MRI

Marcus J. Couch 1,2 , Iain K. Ball 2 , Tao Li 2 , Matthew S. Fox 2 , Birubi Biman 3,4 , and Mitchell S. Albert 1,2

1 Lakehead University, Thunder Bay, Ontario, Canada, 2 Thunder Bay Regional Research Institute, Thunder Bay, Ontario, Canada, 3 Thunder Bay Regional Health Sciences Centre, Thunder Bay, Ontario, Canada, 4 Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada

It is well-known that pulmonary ventilation exhibits a gravitational gradient due to a gradient in regional compliance. 19 F MRI, using inhaled inert fluorinated gases as a signal source, is expected to exhibit strong ventilation gradients, especially since the gas density is high. The purpose of this study was to perform 19 F 3D UTE imaging in healthy volunteers, and to measure anterior/posterior ventilation gradients. This preliminary study demonstrates a clear gravitational distribution gradient of inert fluorinated gases in human lungs, and there is a potential for this technique to provide functional and regional information regarding lung physiology.

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