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Abstract #2302

Quantification of CPMG relaxation rate in MRI of lung tissue

Felix Tobias Kurz 1 , Thomas Kampf 2 , Sabine Heiland 1 , Martin Bendszus 1 , Heinz-Peter Schlemmer 3 , and Christian Herbert Ziener 3

1 Division of Neuroradiology, University of Heidelberg, Heidelberg, Baden-Wrttemberg, Germany, 2 Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany, 3 Radiology, German Cancer Research Center, Heidelberg, Baden-Wrttemberg, Germany

Recently, it has been shown that transverse relaxation rates for Carr-Purcell-Meiboom-Gill (CPMG) sequences in MRI are dependent on interpulse delay time in lung tissue. Here, a symmetry-bound physical model to describe alveolar structure is used within a well-known weak field approximation to provide an expression for transverse relaxation rate that is dependent on interpulse delay time, diffusion, alveolar radius and volumetric ratio of pulmonal air and blood volume. Theoretical results are in good agreement with experimental data for excised rat lung tissue and may be applied to determine in-vivo lung perfusion parameters in intravoxel incoherent motion models or to quantify structural parameters in lung micropathology.

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