Abstract #2285
Comparison of global multiple breath washout measured at the mouth to imaging multiple breath washout in healthy subjects and CF patients.
Felix Horn 1 , Juan Parra-Robles 1 , Helen Marshall 1 , Christopher Taylor 2 , Alex Horsley 3 , and Jim Wild 1
1
Academic Radiology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom,
2
Sheffield
Children's Hospital, Sheffield, South Yorkshire, United
Kingdom,
3
Adult
CF Centre, University of Manchester, Manchester, United
Kingdom
Previously it was shown how gas washout measured with
hyperpolarized helium-3 MRI can be used to obtain
quantitative regional lung function in 3D (MBW-I).
Multiple breath inert gas washout as clinically
performed in the pulmonary function lab (MBW) is a
technique thought to be sensitive to early signs of
ventilation heterogeneity in obstructive lung diseases
like CF. In this preliminary work MBW-I and MBW were
performed in healthy controls and CF patients. MBW-I was
found to be comparable to conventional MBW, an important
pre-requisite for the subsequent regional interpretation
of ventilation heterogeneity.
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