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Abstract #2285

Comparison of global multiple breath washout measured at the mouth to imaging multiple breath washout in healthy subjects and CF patients.

Felix Horn 1 , Juan Parra-Robles 1 , Helen Marshall 1 , Christopher Taylor 2 , Alex Horsley 3 , and Jim Wild 1

1 Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Sheffield Children's Hospital, Sheffield, South Yorkshire, United Kingdom, 3 Adult CF Centre, University of Manchester, Manchester, United Kingdom

Previously it was shown how gas washout measured with hyperpolarized helium-3 MRI can be used to obtain quantitative regional lung function in 3D (MBW-I). Multiple breath inert gas washout as clinically performed in the pulmonary function lab (MBW) is a technique thought to be sensitive to early signs of ventilation heterogeneity in obstructive lung diseases like CF. In this preliminary work MBW-I and MBW were performed in healthy controls and CF patients. MBW-I was found to be comparable to conventional MBW, an important pre-requisite for the subsequent regional interpretation of ventilation heterogeneity.

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