Abstract #2279
Establishing Biomarkers of Gas-Transfer Using Hyperpolarized 129 Xe Dissolved-Phase Spectroscopy in Healthy Volunteers and Subjects with Pulmonary Fibrosis
Suryanarayanan S Kaushik 1,2 , Matthew S Freeman 2,3 , Craig Rackley 4 , Jane Stiles 4 , William M Foster 4 , Justus E Roos 5 , H Page McAdams 5 , and Bastiaan Driehuys 2,5
1
Biomedical Engineering, Duke University,
Durham, NC, United States,
2
Center
for In Vivo Microscopy, Duke University Medical Center,
Durham, NC, United States,
3
Graduate Program
in Medical Physics, Duke University, Durham, NC, United
States,
4
Pulmonary,
Allergy and Critical Care Medicine, Duke University
Medical Center, Durham, NC, United States,
5
Radiology,
Duke University Medical Center, Durham, NC, United
States
When inhaled, the moderate solubility of hyperpolarized
(HP)
129
Xe
gives rise to two distinct resonances, in the barrier
tissue and plasma (197 ppm) and in the RBC (217 ppm).
This dissolved-phase of HP
129
Xe
has emerged as a non-invasive probe of pulmonary
gas-transfer. While the current gold-standard to measure
gas-transfer is DL
CO
, it is highly variable,
and requires good subject compliance. In this work, we
use HP
129
Xe
spectroscopy as a global biomarker of pulmonary
gas-transfer, establish its baseline value in healthy
subjects and show that it is dramatically reduced in
subjects with pulmonary fibrosis.
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