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Abstract #2267

Comparison of T1, T2 and PDFF measured by 1 H MR spectroscopy with histologic fibrosis stage.

Gavin Hamilton 1 , Michael S Middleton 1 , Tanya Wolfson 2 , Anthony C Gamst 2 , Jonathan C Hooker 1 , William M Haufe 1 , Brandon D Ang 3 , Rohit Loomba 3 , and Claude B Sirlin 1

1 Department of Radiology, UC San Diego, San Diego, California, United States, 2 Computational and Applied Statistics Laboratory, SDSC, UC San Diego, San Diego, California, United States, 3 Department of Medicine, UC San Diego, San Diego, California, United States

We developed a rapid multi-TR, multi-TE 1 H MRS sequence for in vivo hepatic fat quantification and characterization that acquires 32 single-average spectra in a single breath-hold. Spectra were acquired without contrast at 3 Tesla in 55 adult subjects who also were undergoing a clinical liver biopsy. T1 and T2 of liver fat and water, and liver proton density fat fraction (PDFF) were measured and compared with histologic fibrosis stage. There were significant differences in water T2 with fibrosis, with higher values being associated with advanced fibrosis.

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