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Abstract #2265

31 P MRSI of the healthy liver at 3T and 7T with AMESING-boosted SNR

Jurgen H. Runge 1 , Wybe J.M. van der Kemp 2 , Dennis W.J. Klomp 2 , Aart J. Nederveen 1 , and Jaap Stoker 1

1 Radiology, Academic Medical Center, Amsterdam, Netherlands, 2 Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Patients with diffuse hepatic disease (e.g. viral hepatitis and NASH) may present with liver fibrosis or inflammation. Preliminary studies indicate that 31 P-MRS may play a role in the non-invasive determination of liver inflammation by mapping NADPH concentration. We compared 2D MRSI at 3T with a SNR optimized 7T set-up and implemented the adiabatic multi-echo spectroscopic imaging sequence (AMESING) of the liver at 7T for further SNR gain. SNR increased by 1.3 to 3.1 between 3T and 7T while AMESING further boosted SNR by 1.2 to 1.6, showing its potential for the quantitative mapping of metabolite concentrations throughout the liver.

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