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Abstract #2250

Improved confidence in IVIM diffusion metrics from post-navigator registration of individual coronal signal average images in abdominal DW-MRI

Neil P Jerome 1 , Matthew R Orton 1 , James d'Arcy 1 , Dow-Mu Koh 2 , David J Collins 1 , and Martin O Leach 1

1 CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom

Blurring, commonly observed in abdominal DWI, arises from respiratory motion between successive acquisitions of signal averages and diffusion gradient directions. Storing coronal DWI images separately allows post-processing alignment by voxel-wise shifting, correcting for a large amount of (predominantly in-plane) respiratory motion. In a volunteer cohort (n=10), residual sum-of-squares as a proxy for uncertainty of IVIM model parameters decreased for renal ROIs following shifting, and further decreased with the exclusion of apparent outlier images. Voxel-wise shifting provides improved confidence in local DWI parameters along with sharper tissue boundaries within images and parameter maps, using a simple and computationally inexpensive method.

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