Abstract #2250
Improved confidence in IVIM diffusion metrics from post-navigator registration of individual coronal signal average images in abdominal DW-MRI
Neil P Jerome 1 , Matthew R Orton 1 , James d'Arcy 1 , Dow-Mu Koh 2 , David J Collins 1 , and Martin O Leach 1
1
CR-UK and EPSRC Cancer Imaging Centre, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
2
Department
of Radiology, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom
Blurring, commonly observed in abdominal DWI, arises
from respiratory motion between successive acquisitions
of signal averages and diffusion gradient directions.
Storing coronal DWI images separately allows
post-processing alignment by voxel-wise shifting,
correcting for a large amount of (predominantly
in-plane) respiratory motion. In a volunteer cohort
(n=10), residual sum-of-squares as a proxy for
uncertainty of IVIM model parameters decreased for renal
ROIs following shifting, and further decreased with the
exclusion of apparent outlier images. Voxel-wise
shifting provides improved confidence in local DWI
parameters along with sharper tissue boundaries within
images and parameter maps, using a simple and
computationally inexpensive method.
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