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Abstract #2248

Intravoxel incoherent motion analysis of abdominal organs: computation of base values in a large cohort of B57Bl/10 mice

Christian Eberhardt 1 , Moritz Wurnig 1 , Andrea Vuck 2 , Mickael Lesurtel 2 , and Andreas Boss 1

1 Department of Diagnostic and Interventional Radiology, University Hospital Zrich, Zrich, Switzerland, 2 Department of Visceral and Transplant Surgery Research, University Hospital Zrich, Zrich, Switzerland

Intravoxel incoherent motion MRI (IVIM-MRI) has lately been increasingly used in clinical studies on a variety of diseases. As animal models are widely used in translational research, the objective of this study was to establish tissue diffusion and perfusion parameters of murine abdominal organs serving as reference for the discrimination of tissue pathologies in animal disease models. Here, the pseudodiffusivity (Dp), tissue diffusivity (Dt) and the perfusion fraction (fp) of the liver, renal cortex, renal medulla, spleen and small bowel were characterized by IVIM- MRI on a large cohort of C57Bl/10 mice (n=50).

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