Abstract #2248
Intravoxel incoherent motion analysis of abdominal organs: computation of base values in a large cohort of B57Bl/10 mice
Christian Eberhardt 1 , Moritz Wurnig 1 , Andrea Vuck 2 , Mickael Lesurtel 2 , and Andreas Boss 1
1
Department of Diagnostic and Interventional
Radiology, University Hospital Zrich, Zrich,
Switzerland,
2
Department
of Visceral and Transplant Surgery Research, University
Hospital Zrich, Zrich, Switzerland
Intravoxel incoherent motion MRI (IVIM-MRI) has lately
been increasingly used in clinical studies on a variety
of diseases. As animal models are widely used in
translational research, the objective of this study was
to establish tissue diffusion and perfusion parameters
of murine abdominal organs serving as reference for the
discrimination of tissue pathologies in animal disease
models. Here, the pseudodiffusivity (Dp), tissue
diffusivity (Dt) and the perfusion fraction (fp) of the
liver, renal cortex, renal medulla, spleen and small
bowel were characterized by IVIM- MRI on a large cohort
of C57Bl/10 mice (n=50).
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