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Abstract #2246

Robust Diffusion-Weighted Single-Shot MRI Can Resolve Major Mice Placental Compartments

Eddy Solomon 1 , Reut Avni 2 , Peter Bendel 3 , Lucio Frydman 1 , and Michal Neeman 2

1 Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2 Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, 3 Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel

Novel diffusion-based MRI methodologies relying on SPatio-temporal ENcoding (SPEN) were developed, and used to uncover in-vivo aspects about the diffusion of fluids in mouse placenta. Macromolecular contrast agents were used to distinguish the ADCs of maternal blood capillaries, fetal blood capillaries and trophblast giant cells. Significantly, different diffusion and perfusion properties were thus noticed, spanning nearly two orders of magnitude. This yields a new multiparametric view of the placenta whereby mainly free diffusion occurs in the maternal blood, a strongly forced perfusion is observed in the fetal microcapillaries, and moderate fluid exchanges characterizes the trophoblasts lining the maternal blood pool.

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