Abstract #2240
Whole-body diffusion-weighted MRI with apparent diffusion coefficient mapping for monitoring multiple myeloma
Shuo Li 1 , Huadan Xue 2 , Jian Li 3 , Haibo Zhang 4 , Zhaoyong Sun 2 , and Zhengyu Jin 2
1
department of radiology, Peking Union
Medical College Hospital, Beijing, Beijing, China,
2
department
of radiology, Peking Union Medical College Hospital,
Beijing, China,
3
department of hematology,
Peking Union Medical College Hospital, Beijing, China,
4
Peking
Union Medical College Hospital, Beijing, China
Purpose: To analyses the diagnostic potential of DWIBS
in the detection and discrimination of focal bone marrow
lesions from multiple myeloma (MM). Methods: A
prospective analysis including 25 MM patients. 12 newly
diagnosed MM patients were divided in active group. 13
MM patients after therapy were divided in stationary
group. The mean ADC value was evaluated in all foci
lesions > 1 cm. Five regions of bone marrow were
calculated. Results: The mean ADC value of active
lesions (n=114) was (880.04212.31)m2/S, which is
significantly lower than that of inactive lesions (n=
80) (1784.29419.17)m2/S. The mean ADC value of
diffusely infiltrated marrow is (632.9143.52)m2/S,
higher than those of stationary period bone
marrow(286.1825.17) m2/S and only focal myeloma bone
marrow(420.2531.11) m2/S. Coclusion: The ADC value
allows differentiation between active and stationary
myeloma lesions, normal bone marrow and tumors of
myeloma.
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