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Abstract #2240

Whole-body diffusion-weighted MRI with apparent diffusion coefficient mapping for monitoring multiple myeloma

Shuo Li 1 , Huadan Xue 2 , Jian Li 3 , Haibo Zhang 4 , Zhaoyong Sun 2 , and Zhengyu Jin 2

1 department of radiology, Peking Union Medical College Hospital, Beijing, Beijing, China, 2 department of radiology, Peking Union Medical College Hospital, Beijing, China, 3 department of hematology, Peking Union Medical College Hospital, Beijing, China, 4 Peking Union Medical College Hospital, Beijing, China

Purpose: To analyses the diagnostic potential of DWIBS in the detection and discrimination of focal bone marrow lesions from multiple myeloma (MM). Methods: A prospective analysis including 25 MM patients. 12 newly diagnosed MM patients were divided in active group. 13 MM patients after therapy were divided in stationary group. The mean ADC value was evaluated in all foci lesions > 1 cm. Five regions of bone marrow were calculated. Results: The mean ADC value of active lesions (n=114) was (880.04212.31)m2/S, which is significantly lower than that of inactive lesions (n= 80) (1784.29419.17)m2/S. The mean ADC value of diffusely infiltrated marrow is (632.9143.52)m2/S, higher than those of stationary period bone marrow(286.1825.17) m2/S and only focal myeloma bone marrow(420.2531.11) m2/S. Coclusion: The ADC value allows differentiation between active and stationary myeloma lesions, normal bone marrow and tumors of myeloma.

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