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Abstract #2216

Effect of chemoradiation on cervical cancer tumor oxygenation, using Blood Oxygen Level Dependent (BOLD) MRI

James J Brittin 1 , Elizabeth A Sadowski 1 , Kristin A Bradley 2 , Emily F Dunn 2 , and Jessica B Robbins 1

1 Radiology, University of Wisconsin, Madison, Wisconsin, United States, 2 Radiation Oncology, University of Wisconsin, Madison, Wisconsin, United States

BOLD MRI sequences can non-invasively measure oxygen bioavailability in different tissues throughout the body, including the uterine cervix. In our retrospective study involving 11 patients with cervical cancer, we found that treatment with chemoradiation, including high dose intracavitary brachytherapy resulted in decreased cervical tumor oxygenation (P=0.001), possibly due to reduced angiogenesis, reduced tumor volume, and/or increased fibrotic tissue formation. As tumor hypoxia has been shown to be a powerful prognostic indicator for poor outcomes in cervical cancer as well as multiple other malignancies, BOLD MRI may be useful in differentiating between tumors which will and will not be radiosensitive.

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