Abstract #2216
Effect of chemoradiation on cervical cancer tumor oxygenation, using Blood Oxygen Level Dependent (BOLD) MRI
James J Brittin 1 , Elizabeth A Sadowski 1 , Kristin A Bradley 2 , Emily F Dunn 2 , and Jessica B Robbins 1
1
Radiology, University of Wisconsin, Madison,
Wisconsin, United States,
2
Radiation
Oncology, University of Wisconsin, Madison, Wisconsin,
United States
BOLD MRI sequences can non-invasively measure oxygen
bioavailability in different tissues throughout the
body, including the uterine cervix. In our retrospective
study involving 11 patients with cervical cancer, we
found that treatment with chemoradiation, including high
dose intracavitary brachytherapy resulted in decreased
cervical tumor oxygenation (P=0.001), possibly due to
reduced angiogenesis, reduced tumor volume, and/or
increased fibrotic tissue formation. As tumor hypoxia
has been shown to be a powerful prognostic indicator for
poor outcomes in cervical cancer as well as multiple
other malignancies, BOLD MRI may be useful in
differentiating between tumors which will and will not
be radiosensitive.
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