Abstract #2214
Quantification of Iron Oxide Nanoparticles in a large animal model using MRI
Oliviero L Gobbo 1 , Andrew J Fagan 2 , Colin Ryan 3 , Deirdre Edge 4 , Christine Shortt 4 , Marek Radomski 3 , Adriele Prina-Mello 5 , Farouk Markos 4 , and Yuri Volkov 5
1
School of Pharmacy and Pharmaceutical
Sciences and TCIN, Trinity College Dublin, Dublin,
Leinster, Ireland,
2
Centre
for Advanced Medical Imaging (CAMI), St Jamess Hospital
/ Trinity College Dublin, Dublin, Ireland,
3
School
of Pharmacy and Pharmaceutical Sciences, Trinity College
Dublin, Dublin, Ireland,
4
Physiology
Department, University College Cork, Cork, Ireland,
5
School
of Medicine, Trinity College Dublin, Dublin, Ireland
MULTIFUN consortium's current goal is to develop and
validate multifunctional SPION for the early detection
and treatment of breast and pancreatic cancer while
reducing side effects for patients compared to
conventional treatment with anti-cancer drugs. This
joint therapeutic and diagnostic property has been
called theranostic. Our study establishes an MRI
protocol for the quantification of SPIONs in ex-vivo pig
organs (i.e. kidneys) which can potentially be used in
preclinical cancer research and in translational
medicine.
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