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Abstract #2196

Optimal measurement of arterial input function in MR renography using saturation recovery

Christopher C. Conlin 1 , Jeff L. Zhang 1 , Marta E. Heilbrun 1 , Kristi Carlston 1 , Daniel Kim 1 , Kathryn A. Morton 1 , and Vivian S. Lee 1

1 Department of Radiology, University of Utah, Salt Lake City, Utah, United States

This study compares long and short inversion times (TIs) for measuring arterial input functions (AIFs) from saturation recovery images in the estimation of glomerular filtration rate (GFR) from low dose Gd-enhanced MR renography. Long TIs may result in saturated signal and therefore an inaccurate estimate of Gd concentration which is required for GFR calculation. Short TIs may suffer from low SNR. By comparing GFR estimates obtained at short and long TIs to reference measurements from 99mTc-DTPA clearance, it was found that relatively long TIs should be used to avoid accumulation of AIF error into the estimated GFR.

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