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Abstract #2193

Characterizing the microstructural and architectural organization of healthy kidney tissue using diffusion tensor imaging, fiber tractography and intra-voxel incoherent motion.

Sophie van Baalen 1 , Alexander Leemans 2 , Pieter Dik 1 , Bennie ten Haken 3 , and Martijn Froeling 2

1 Pediatric Urology, University Medical Centre Utrecht/ WKZ, Utrecht, Netherlands, 2 Imaging science institute, University Medical Centre Utrecht, Utrecht, Netherlands, 3 Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Netherlands

For imaging of kidney pathologies, the use of endogenous contrast is important, because contrast agents can further damage renal function. MRI-DTI and IVIM are promising imaging techniques for kidney imaging because they enable to measure the extent and direction of water diffusion and the perfusion fraction, respectively. In this study we used MRI-DTI and IVIM to visualize the microstructural properties of kidney tissues. With MRI-DTI and tractography, the radially orientation of the tubules and vascular network in the renal medulla is reflected by radially oriented tracts, originating in the cortex and convolving in multiple papillae. With IVIM, blood perfusion and urine diffusion fractions can be visualized for different kidney tissues.

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