Abstract #2163
Pharmakokinetic modeling and quantification of the liver function using DCE-MRI with contrast agent Gd-EOB-DTPA
Patrick Zylka 1 , Timm Denecke 2 , Dominik Geisel 2 , and Lutz Ldemann 1
1
Klinik und Poliklinik fr Strahlentherapie,
Universittsklinikum Essen, Essen, NRW, Germany,
2
Klinik
fr Radiologie, Charit Universittsmedizin Berlin,
Berlin, NRW, Germany
We investigate the possibility to establish a
mathematical model which is able to describe liver
parameters noninvasive and space-resolved by magnetic
resonance imaging (DCE-MRI). We use Gd-EOB-DTPA as
contrast agent which is metabolized by healthy
hepatocytes whereas the metabolism of damaged cells is
strongly suppressed. Determing the rate of metabolism we
can compare liver regions to quantify the degree of
function loss. After converting voxel signal to
relaxation rate (which is proportional to the contrast
agent concentration), the data of a chosen liver area is
handed to a computer program. The algorithm is based on
a two-compartment-model and returns the parameters
"overall flow", mean transit time, "hepatic input /
extraction rate" as well as the compartment volumes.
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