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Abstract #2146

T 2 * from fat-water MRI is sensitive to local adipose tissue inflammatory changes in a diet-induced obesity mouse model at 15T

Henry H. Ong 1,2 , Corey D. Webb 3 , Marnie L. Gruen 3 , Alyssa H. Hasty 3 , John C. Gore 1,2 , and E. Brian Welch 1,2

1 Vanderbilt University Institute of Imaging Sciences, Nashville, TN, United States, 2 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3 Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, United States

In obesity, fat-water MRI (FWMRI) methods provide valuable information on adipose tissue (AT) distribution. AT is known to undergo complex metabolic and endocrine changes in association with chronic inflammation. We investigated the potential for quantitative FWMRI to be sensitive to AT inflammatory changes in an established diet-induced obesity mouse model. We examined T 2 * estimates from the fat-water separation algorithm and observed an increasing shift toward higher T 2 * values in perirenal AT with increasing obesity as compared with normal weight mice. Quantitative FWMRI T 2 * measurement shows potential for longitudinal non-invasive assessment of AT dysfunction in obesity.

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