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Abstract #2143

Quantification of total adipose tissue in fetal guinea pigs subjected to suboptimal in utero conditions using water-fat MRI

Kevin J Sinclair 1 , Lanette J Friesen-Waldner 1 , Colin M McCurdy 1 , Curtis N Wiens 2 , Trevor P Wade 1,3 , Barbra de Vrijer 4 , Timothy RH Regnault 4,5 , and Charles A McKenzie 1,3

1 Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada, 2 Department of Radiology, University of Wisconsin, Madison, Wisconsin, United States, 3 Robarts Research Institute, University of Western Ontario, London, Ontario, Canada, 4 Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada, 5 Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada

The metabolic syndrome is a cluster of morbidities that lead to an increased risk of developing cardiovascular disease. Studies suggest that the propensity to develop the metabolic syndrome can be programmed during fetal development. In this study, adipose tissue distributions in guinea pig fetuses were monitored using water-fat MRI. The fetuses were subjected to 3 different in utero conditions: over-nourishment, under-nourishment, and appropriate nourishment of the fetus. T1- and T2-weighted, as well as IDEAL water-fat images were acquired. Increased total adipose tissue was seen in the over-nourished case, while under-nourished fetuses had decreased total adipose tissue compared to normal.

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