Quantification of triglyceride fatty acid composition in the fatty liver, subcutaneous and visceral adipose tissues with 3.0T MRI.
Benjamin Leporq 1 , Simon Auguste Lambert 1 , Helene Ratiney 2 , Gaspard D'Assignies 1,3 , Maxime Ronot 1,3 , Valerie Vilgrain 1,3 , Olivier Beuf 2 , and Bernard Van Beers 1,3
Center for research on inflammation,
Universit PARIS 7 ; INSERM U1149, Paris, France,
CNRS UMR 5220; INSERM U1044; INSA Lyon; UCBL Lyon 1,
Universite de Lyon, Villeurbanne, France,
hospital; Department of radiology, Assistance Publique
Hopitaux de Paris, Clichy, France
The aim of our study was to validate a 3.0T MRI method
for quantifying triglyceride fatty acid (FA)
composition. A 3D spoiled gradient multiple echoes
sequence was used to acquire magnitude and phase images.
Native phase images were corrected for wrap, zero- and
first-order phase to rebuild the real part images. A
model built upon a nine component fat 1H MR spectrum was
used to derive three FA composition related parameters:
the number of double bonds (ndb), the chain length (CL)
and the number of methylene interrupted double bond
(nmidb). Linear regressions showed a strong agreement
between ndb, nmidb quantified with MRI on eight
vegetables oils and the theoretical values calculated
using oil composition. Measurements performed in the
liver, in subcutaneous and visceral adipose tissues were
consistent with previously published data.
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