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Abstract #2137

Quantification of triglyceride fatty acid composition in the fatty liver, subcutaneous and visceral adipose tissues with 3.0T MRI.

Benjamin Leporq 1 , Simon Auguste Lambert 1 , Helene Ratiney 2 , Gaspard D'Assignies 1,3 , Maxime Ronot 1,3 , Valerie Vilgrain 1,3 , Olivier Beuf 2 , and Bernard Van Beers 1,3

1 Center for research on inflammation, Universit PARIS 7 ; INSERM U1149, Paris, France, 2 CREATIS CNRS UMR 5220; INSERM U1044; INSA Lyon; UCBL Lyon 1, Universite de Lyon, Villeurbanne, France, 3 Beaujon hospital; Department of radiology, Assistance Publique Hopitaux de Paris, Clichy, France

The aim of our study was to validate a 3.0T MRI method for quantifying triglyceride fatty acid (FA) composition. A 3D spoiled gradient multiple echoes sequence was used to acquire magnitude and phase images. Native phase images were corrected for wrap, zero- and first-order phase to rebuild the real part images. A model built upon a nine component fat 1H MR spectrum was used to derive three FA composition related parameters: the number of double bonds (ndb), the chain length (CL) and the number of methylene interrupted double bond (nmidb). Linear regressions showed a strong agreement between ndb, nmidb quantified with MRI on eight vegetables oils and the theoretical values calculated using oil composition. Measurements performed in the liver, in subcutaneous and visceral adipose tissues were consistent with previously published data.

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