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Abstract #2125

Quantification of gastrointestinal liquid volumes following a 240 mL dose of water

Kathryn Murray 1 , Deanna Mudie 2 , Susan Pritchard 1 , Caroline Hoad 1 , Martin Garnett 3 , Gordon Amidon 2 , Penny Gowland 1 , Robin Spiller 4 , Gregory Amidon 2 , and Luca Marciani 4

1 Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottingham, United Kingdom, 2 College of Pharmacy, University of Michigan, MI, United States, 3 School of Pharmacy, University of Nottingham, Nottingham, United Kingdom, 4 Nottingham Digestive Diseases Centre and Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom

Drug dissolution and absorption from solid oral dosage forms is highly dependent on the presence of liquid in the gut, but little is known about liquid volumes and distribution in vivo. This study detailes the time courses of the volume and number of liquid pockets in the upper gut of 12 healthy individuals following the ingestion of the industry standard 240 mL dose of water using MRI. These novel insights will help improve physiological relevance of modeling for prediction of bioperformance of low solubility oral solid dosage forms.

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