Abstract #2125
Quantification of gastrointestinal liquid volumes following a 240 mL dose of water
Kathryn Murray 1 , Deanna Mudie 2 , Susan Pritchard 1 , Caroline Hoad 1 , Martin Garnett 3 , Gordon Amidon 2 , Penny Gowland 1 , Robin Spiller 4 , Gregory Amidon 2 , and Luca Marciani 4
1
Sir Peter Mansfield Magnetic Resonance
Centre, School of Physics and Astronomy, University of
Nottingham, Nottingham, Nottingham, United Kingdom,
2
College
of Pharmacy, University of Michigan, MI, United States,
3
School
of Pharmacy, University of Nottingham, Nottingham,
United Kingdom,
4
Nottingham
Digestive Diseases Centre and Nottingham Digestive
Diseases Biomedical Research Unit, University of
Nottingham, Nottingham, United Kingdom
Drug dissolution and absorption from solid oral dosage
forms is highly dependent on the presence of liquid in
the gut, but little is known about liquid volumes and
distribution in vivo. This study detailes the time
courses of the volume and number of liquid pockets in
the upper gut of 12 healthy individuals following the
ingestion of the industry standard 240 mL dose of water
using MRI. These novel insights will help improve
physiological relevance of modeling for prediction of
bioperformance of low solubility oral solid dosage
forms.
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