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Abstract #2116

Preliminary investigations of colonic motility from Cine MRI; use of registration techniques for quantitative analysis

Caroline L. Hoad 1 , Valentin Hamy 2 , Klara Garsed 3 , Luca Marciani 3 , Robin C. Spiller 3 , Stuart A. Taylor 2 , David Atkinson 2 , Penny A. Gowland 1 , and Alex Menys 2

1 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 Centre for Medical Imaging, Division of Medicine, UCL, London, United Kingdom, 3 Nottingham Digestive Disease Centre, Biomedical Research Unit in GI and Liver Diseases, University Hospitals NHS Trust and University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

This study describes a preliminary investigation of the use of registration techniques to assess colonic motility. Cine MRI data from 10 healthy subjects pre- and 1 hour post an oral dose of a common laxative underwent dual registration to remove breathing effects and parameterise bowel motion. Significant area changes from 3 regions of interest across the AC were converted into a motility index and compared to observer scores of bowel wall contractions. The greatest agreement between the motility index and observer scores were seen for a change in area of greater than 5% of mean area.

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