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Abstract #2114

Quantitative assessment of global small bowel motility in Chronic Intestinal Pseudo-Obstruction and controls: A Preliminary Study

Alex Menys 1 , Shamaila Butt 2 , Anton Emmanuel 2 , Natalia Zarate 2 , David Atkinson 3 , Andrew Plumb 3 , and Stuart A Taylor 3

1 Centre for Medical Imaging, UCL, London, Select, United Kingdom, 2 GI Physiology Unit, UCLH, London, United Kingdom, 3 Centre for Medical Imaging, UCL, London, United Kingdom

Quantified small bowel (SB) motility, assessed by analysis of dynamic MRI images, is an emerging tool for the investigation of dysmotility in a range of diseases. In this study, we report the initial findings with respect to global SB motility in a group of Chronic Intestinal pseudo-obstruction patients against healthy controls. We found a significant difference in basal small bowel motility between groups and, upon challenge with a pro-kinetic drug, increases in bowel motility in both groups. This study demonstrates the first clinical application of global SB motility analysis and encouraging results for the quantitative investigation of dysmotility in disease.

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