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Abstract #2111

Dorzolamide Restores Choroidal Blood Flow in the DBA/2J Mouse Model of Glaucoma

Saurav B Chandra 1 , Eric R Muir 1 , and Timothy Q Duong 1

1 Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

Dorzolamide (DZ) is clinically used to treat glaucoma by reducing intraocular pressure. However, its effect on blood flow is unknown. The goal of this study is to investigate the effect of topical DZ application on retinal and choroidal blood flow in DBA/2J mice, an established mouse model of glaucoma. Results are compared with C57BL/6J mice, used as a control group. This study indicates increased blood flow in the choroid of both DBA/2J as well as C57BL/6J mice models following topical application of Dorzolamide.

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