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Abstract #2108

Long term 7 Tesla MRI and behavioral study on status-epilepticus induced neurodegeneration in rat and possible neuroprotective treatment

Xiao-Qi Ding 1 , Martin Meier 2 , Marion Bankstahl 3 , Xiangyu Tang 1,4 , Wolfgang Lscher 3 , Heinrich Lanfermann 1 , and Jens P. Bankstahl 5

1 Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Lower Saxony, Germany, 2 Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Lower Saxony, Germany, 3 Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Lower Saxony, Germany, 4 Department of Radiology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China, 5 Preclinical Molecular Imaging, Department of Nuclear Medicine, Hannover Medical School, Hannover, Lower Saxony, Germany

Status epilepticus (SE) is a common insult that may lead to development of temporal lobe epilepsy characterized by hippocampal neurodegeneration, which is associated with psychological and cognitive dysfunctions. The present work investigated SE-induced neurodegeneration and behavioral dysfunction as well as possible neuroprotective treatment in rat by long term MRI follow-up study combined with a behavioral test battery. The results showed that SE-induced neurodegeneration is a long lasting process associated with behavioral changes that can be reduced by add-on treatment with phenobarbital.

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