Abstract #2108
Long term 7 Tesla MRI and behavioral study on status-epilepticus induced neurodegeneration in rat and possible neuroprotective treatment
Xiao-Qi Ding 1 , Martin Meier 2 , Marion Bankstahl 3 , Xiangyu Tang 1,4 , Wolfgang Lscher 3 , Heinrich Lanfermann 1 , and Jens P. Bankstahl 5
1
Institute of Diagnostic and Interventional
Neuroradiology, Hannover Medical School, Hannover, Lower
Saxony, Germany,
2
Institute
of Laboratory Animal Science, Hannover Medical School,
Hannover, Lower Saxony, Germany,
3
Department
of Pharmacology, Toxicology and Pharmacy, University of
Veterinary Medicine, Hannover, Lower Saxony, Germany,
4
Department
of Radiology, Tongji Medical College of Huazhong
University of Science and Technology, Wuhan, Hubei,
China,
5
Preclinical
Molecular Imaging, Department of Nuclear Medicine,
Hannover Medical School, Hannover, Lower Saxony, Germany
Status epilepticus (SE) is a common insult that may lead
to development of temporal lobe epilepsy characterized
by hippocampal neurodegeneration, which is associated
with psychological and cognitive dysfunctions. The
present work investigated SE-induced neurodegeneration
and behavioral dysfunction as well as possible
neuroprotective treatment in rat by long term MRI
follow-up study combined with a behavioral test battery.
The results showed that SE-induced neurodegeneration is
a long lasting process associated with behavioral
changes that can be reduced by add-on treatment with
phenobarbital.
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