Abstract #2085
Gray matter demyelination and remyelination detected with multimodal quantitative analysis at 11.7T in a mouse model of multiple sclerosis.
Alexandra Petiet 1 , Marie-Stphane Aigrot 2 , and Bruno Stankoff 2,3
1
Center for Neuroimaging Research, Brain and
Spine Institute, Paris, Ile-de-France, France,
2
UPMC
/ INSERM UMR975, Brain and Spine Institute Research
Center, Paris, Ile-de-France, France,
3
APHP,
Tenon Hospital, Paris, Ile-de-France, France
Myelin is a component of the nervous system that is
disrupted in multiple sclerosis, resulting in
neuro-axonal degeneration. We investigated the
longitudinal effect of chronic cuprizone-induced
demyelination in the brain of treated vs untreated mice
at 11.7T. Signal intensity ratios, T2 values, and
diffusion metrics measurements showed significant and
reversible modifications in the corpus callosum, the
external capsule, the cerebellum, the caudate putamen,
the thalamus, and the cortex of treated mice. These
multimodal data will provide better understanding of the
MR signal specificity for myelin assessment, and will be
the basis to test therapies against gray matter
demyelination.
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