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Abstract #2085

Gray matter demyelination and remyelination detected with multimodal quantitative analysis at 11.7T in a mouse model of multiple sclerosis.

Alexandra Petiet 1 , Marie-Stphane Aigrot 2 , and Bruno Stankoff 2,3

1 Center for Neuroimaging Research, Brain and Spine Institute, Paris, Ile-de-France, France, 2 UPMC / INSERM UMR975, Brain and Spine Institute Research Center, Paris, Ile-de-France, France, 3 APHP, Tenon Hospital, Paris, Ile-de-France, France

Myelin is a component of the nervous system that is disrupted in multiple sclerosis, resulting in neuro-axonal degeneration. We investigated the longitudinal effect of chronic cuprizone-induced demyelination in the brain of treated vs untreated mice at 11.7T. Signal intensity ratios, T2 values, and diffusion metrics measurements showed significant and reversible modifications in the corpus callosum, the external capsule, the cerebellum, the caudate putamen, the thalamus, and the cortex of treated mice. These multimodal data will provide better understanding of the MR signal specificity for myelin assessment, and will be the basis to test therapies against gray matter demyelination.

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