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Abstract #2053

Comparison of Susceptibility-Weighted-Imaging determined vessel diameters to histological measures

Gnther Grabner 1 , Assunta Dal-Bianco 2 , Hans Lassmann 3 , Siegfried Trattnig 1 , and Simon Hametner 3

1 MR Centre of Excellence, Department of Biomedical Imaging und Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2 Department of Neurology, Medical University of Vienna, Vienna, Austria, 3 Center for Brain Research, Medical University of Vienna, Vienna, Austria

Susceptibility-Weighted-Imaging allows high resolution imaging of the venous system. However, the real size of the imaged veins remains unknown. The purpose of this study was to determine the relation between apparent SWI vessel sizes and real vessel diameters measured on histological tissue. Two in-vitro SWI acquisitions were performed, one on a healthy and one on a multiple sclerosis brain. Furthermore we compared the SWI enlargement factor in healthy brain tissue to the MS brain. Results indicate an SWI enlargement factor of about 3.7 for vessels with a histological diameter below 100 m independently from disease status.

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