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Abstract #2047

Cerebrovascular reactivity as objective markers of hemodynamic compromise: A pilot study

Olivia Sobczyk 1,2 , Daniel M. Mandell 2 , Kevin Sam 2,3 , Adrian Crawley 2 , Julien Poublanc 2 , David Mikulis 2 , James Duffin 3,4 , and Joseph Fisher 3,4

1 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, 2 Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada, 3 Department of Physiology, University of Toronto, Toronto, Ontario, Canada, 4 Anaesthesiology, University Health Network, Toronto, Ontario, Canada

We used cerebrovascular reactivity (CVR), the change in cerebral blood flow, as measured using BOLD MRI in response to a hypercapnic vasodilatory stimulus to test neurovascular reserve. We scored CVR values voxel-by-voxel in terms of statistical differences from the corresponding voxel in a cohort of healthy subjects. We averaged the z-scores in the MCA territories in a cohort of patients with steno-occlusive disease and in healthy subjects. Frequency distribution histograms showed only a small overlap in average z-values between patients and healthy subjects suggesting this analysis may be a sensitive and specific objective discriminator for steno-occlusive disease.

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