Abstract #2047
Cerebrovascular reactivity as objective markers of hemodynamic compromise: A pilot study
Olivia Sobczyk 1,2 , Daniel M. Mandell 2 , Kevin Sam 2,3 , Adrian Crawley 2 , Julien Poublanc 2 , David Mikulis 2 , James Duffin 3,4 , and Joseph Fisher 3,4
1
Institute of Medical Science, University of
Toronto, Toronto, Ontario, Canada,
2
Department
of Medical Imaging, University Health Network, Toronto,
Ontario, Canada,
3
Department of Physiology,
University of Toronto, Toronto, Ontario, Canada,
4
Anaesthesiology,
University Health Network, Toronto, Ontario, Canada
We used cerebrovascular reactivity (CVR), the change in
cerebral blood flow, as measured using BOLD MRI in
response to a hypercapnic vasodilatory stimulus to test
neurovascular reserve. We scored CVR values
voxel-by-voxel in terms of statistical differences from
the corresponding voxel in a cohort of healthy subjects.
We averaged the z-scores in the MCA territories in a
cohort of patients with steno-occlusive disease and in
healthy subjects. Frequency distribution histograms
showed only a small overlap in average z-values between
patients and healthy subjects suggesting this analysis
may be a sensitive and specific objective discriminator
for steno-occlusive disease.
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