Measuring vascular reactivity with breath-holds after stroke: implications for fMRI study interpretation
Kevin Murphy 1 , Richard J.S. Wise 2 , and Fatemeh Geranmayeh 2
CUBRIC, School of Psychology, Cardiff
University, Cardiff, Wales, United Kingdom,
Cognitive and Clinical Neuroimaging Laboratory, Imperial
College London, United Kingdom
BOLD fMRI is a widely used technique to map brain
function and monitor its recovery after stroke.
Impairments in cerebrovascular reactivity (CVR) will
alter neurovascular coupling causing BOLD
interpretability problems. This study demonstrates that
CVR can be measured successfully using a breath-hold
task in a stroke population. Reduced CVR in the stroke
penumbra limits the interpretability of the BOLD signal
in that area in comparisons with controls. However,
since CVR in the penumbra remains unchanged over time, a
finding of increased penumbral activity in a
longitudinal study is less likely to be due to changes
in vascular reactivity.
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