Abstract #2019
Using Advanced MR Techniques to Investigate Traumatic Brain Injury
Iain David Croall 1 , Christopher Cowie 2 , Jiabao He 3 , Anna Peel 1 , Joshua Wood 1 , Benjamin Aribisala 4 , Patrick Mitchell 2 , David Mendelow 2 , Fiona Smith 1 , David Millar 5 , Thomas Kelly 2 , and Andrew Blamire 1
1
Magnetic Resonance Centre, Newcastle
University, Newcastle upon Tyne, Tyne and Wear, United
Kingdom,
2
Newcastle
upon Tyne Hospitals NHS Foundation Trust, Tyne and Wear,
United Kingdom,
3
Aberdeen
Biomedical Imaging Centre, University of Aberdeen,
Aberdeen, Aberdeen, United Kingdom,
4
Brain
Research Imaging Centre, University of Edinburgh,
Edinburgh, United Kingdom,
5
Neurocog,
Tyne and Wear, United Kingdom
Diffuse axonal injury resulting from Traumatic Brain
Injury (TBI) can be investigated using advanced MR
techniques. While different modalities are specialised
for specific analyses, little research has combined
techniques. We present a joint Diffusion Tensor Imaging
(DTI) and Magnetic Resonance Spectroscopy investigation
examining mildly injured TBI patients at 6 days
post-injury. Regarding the DTI findings, we present a
new conclusion on the previously unusual and contentious
finding of increased fractional anisotropy, while a
novel result of increased N-acetylaspartate and evidence
of creatine alterations post-injury are reported
following Spectroscopy analysis. Additionally, these
physical changes are correlated with measures of
cognitive functioning.
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