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Abstract #2006

Brain Network Dysfunction in Young Athletes with Persistent Post-Concussion Syndrome

Marjorie Villien 1 , Brian Edlow 2 , Elissa McIntosh 2 , Maulik P. Purohit 3 , Andre van der Kouwe 1 , Janet C. Sherman 2 , David Greer 4 , Ross Zafonte 3 , and Ona Wu 1

1 Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Boston, MA, United States, 2 Massachusetts General Hospital, Boston, MA, United States, 3 Spaulding Rehabilitation Hospital, Boston, MA, United States, 4 Yale School of Medicine, New Haven, CT, United States

Traumatic brain injury (TBI) is one of the leading causes of morbidity in the US, with the highest incidence among young adults. The majority of mild TBI patients recover within a few months, but for up to 20% symptoms persist and lead to a devastating impact on interpersonal relationships and potentially to long-term disability, named as persistent post-concussion syndrome (PPCS). The pathophysiological basis of PPCS remains unknown. This resting state fMRI study demonstrates that multiple resting brain networks are altered in young athletes with PPCS and also suggest that the inferior parietal lobule is implicated in the pathogenesis of PPCS.

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