Multiparametric MRI characterization of NBO treatment following mild Traumatic Brain Injury
Justin Alexander Long 1 , Lora Talley Watts 1 , Jonathan Chemello 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Duong 1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States
This study investigated the spatiotemporal dynamics of
diffusion, T2 and fractional anisotropy associated with
mild traumatic brain injury (TBI) following NBO
treatment. Diffusion, T2 and fractional anisotropy
changes generally indicated that lesion severity
increased following administration of NBO treatment
compared to the air treated control group. T2 increased
in the NBO treatment groups initially (3 hrs and day 1
measures), returning to similar magnitude as the air
treated control group by Day 2 and then showed a
significant increase by 14 days post injury. ADC and FA
differences were significant at all time points.
Multi-parametric MRI offers a range of biomarkers that
are sensitive to different tissue types at different
stages of TBI and can distinguish differences in outcome
based on treatments applied.
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