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Abstract #2000

White Matter Impairment in Depression and Hypertension: A Diffusion Kurtosis Imaging Study at 3-T MR

Xiangzhu Zeng 1 , Huishu Yuan 1 , Ying Liu 1 , Zheng Wang 1 , and Han Zhang 2

1 Dept of Radiology, Peking University Third Hospital, Beijing, Beijing, China, 2 Dept of the consultation liaison, Peking University Mental Health Institute, Beijing, Beijing, China

As a new diagnostic tool for cerebral microstructure impairment, Diffusion Kurtosis imaging (DKI) has the ability to assess the white matter impairment of tissues by investigating water diffusion with a non-Gaussian model. Mean kurtosis(MK) is a key parameters of DKI and reveals the white matter damage accurately. This work evaluates the diagnostic utilities of MK in the case of depression and hypertension and specifies the white matter impairment in these patients.

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