Abstract #1998
Cortical thickness correlates with symptoms in adolescents newly diagnosed with Obsessive-Compulsive Disorder
Oscar Gustafsson 1,2 , Maria Ljungberg 1,2 , Arvid Carlsson 3 , Maria L Carlsson 3 , Eva Forssell-Aronsson 1,2 , Tord Ivarsson 4 , Lars Jnsson 5 , Karin Melin 4 , and Gran Starck 1,2
1
Division of Medical Physics and Medical
Engineering, Sahlgrenska University Hospital, Gteborg,
Sweden,
2
Department
of Radiation Physics, Gteborg University, Gteborg,
Sweden,
3
Institute
of Neuroscience and Physiology, Gteborg University,
Gteborg, Sweden,
4
Department
of Child & Adolescent Psychiatry, Gteborg University,
Gteborg, Sweden,
5
Department
of Radiology, Sahlgrenska University Hospital, Gteborg,
Sweden
A morphometric analysis of treatment-nave adolescents
newly diagnosed with obsessive-compulsive disorder (OCD),
utilizing the image analysis software FreeSurfer, was
performed. Cortical thickness and volume of subcortical
structures was examined with a multivariate method
(scaled subprofile modeling) which produces patterns of
areas related to the disorder. Analysis of difference
between patients compared to healthy controls and
correlation to symptom severity, measured with the
Childrens Yale-Brown Obsessive-Compulsive Scale (CYBOCS),
were performed. A significant correlation between
cortical thickness and CYBOCS was found. Areas of major
effect in the corresponding pattern included the left
fusiform gyrus and the left parietal lobe.
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