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Abstract #1993

Alteration of developmental trajectory of temporal lobe grey matter in ADHD boys

Qi Liu 1 , Lizhou Chen 1 , Xinyu Hu 1 , Ying Chen 1 , Fei Li 1 , Yuanyuan Li 1 , Ning He 1 , Lanting Guo 1 , Qiyong Gong 1 , and Xiaoqi Huang 1

1 West China Hospital of Sichuan University, Chengdu, Sichuan, China

Abnormal Gray matter volume (GMV) has been suggested to be an important neuroimaging biomarker of Attention Deficits/Hyperactivity Disorders (ADHD). Present study compared GMV of drug-nave ADHD boys with well-matched controls using voxel-based morpphometry analysis, and explored the age effect as well as correlation with neuropsychological measurements. Decreased GMV was revealed in bilateral temporal lobes extending to amygdala, which showed positive correlation with some cognitive functions. Moreover, no significant correlation was found between GMV with age in ADHD boys, as seen in healthy controls, which might indicate an abnormal developmental trajectory of GMV in ADHD.

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