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Abstract #1991

Less dynamic functional brain network in schizophrenia

Hu Cheng 1 , Sharlene Newman 1 , Joaquin Goni Cortes 1 , Jerillyn S. kent 1 , Josselyn Howell 1 , Amanda Bolbecker 1 , Aina Puce 1 , Brian F. O'Donnell 1 , and william P. Hetrick 1

1 Indiana University, Bloomington, IN, United States

Recent studies indicate less dynamic brain function in schizophrenia patients. Because head motion and other confounds can affect the FC and its variability, investigation of FC dynamics by directly comparing FC over time can be invalid. We propose a method to tackle this problem. By constructing two FCs from interleaved time points of the resting state time course, we can extract the variance of FC irrelevant to brain dynamics, and use it as a baseline in the evaluation of FC change. Using this approach, we found that the schizophrenia patients exhibited smaller variations of functional network compared to normal controls.

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