Abstract #1977
Structural deficits of mirror neuron system in autism spectrum disorder
Hsiang-Yun Chien 1 , Yung-Chin Hsu 1 , Yu-Jen Chen 1 , Yu-Chun Lo 1 , Yao-Chia Shih 1 , Susan Shur Fen Gau 2 , and Wen-Yih Isaac Tseng 1
1
Center for Optoelectronic Medicine, National
Taiwan University College of Medicine, Taipei, Taiwan,
Taiwan,
2
Department
of Psychiatry, National Taiwan University Hospital and
College of Medicine, Taiwan, Taiwan
Autism Spectrum Disorder (ASD) is a neurodevelopmental
disorder featuring the deficits of social communication
and interactions. Past studies have reported that mirror
neuron system (MNS), which is important for human social
development by imitation, shows functional deficient in
the social imitation tasks. In current study, we
hypothesize the structural connectivity in MNS would
also be abnormal in ASD patients. By analyzing the
cortical thickness and fiber tracks of specific MNS
regions, we found that the bilateral pars opercularis
has thinner cortical thickness and the commissural fiber
between them also shows abnormal in ASD group. The
preliminary result implies the structural deficits of
MNS in ASD patients.
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