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Abstract #1977

Structural deficits of mirror neuron system in autism spectrum disorder

Hsiang-Yun Chien 1 , Yung-Chin Hsu 1 , Yu-Jen Chen 1 , Yu-Chun Lo 1 , Yao-Chia Shih 1 , Susan Shur Fen Gau 2 , and Wen-Yih Isaac Tseng 1

1 Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Taiwan, 2 Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taiwan, Taiwan

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder featuring the deficits of social communication and interactions. Past studies have reported that mirror neuron system (MNS), which is important for human social development by imitation, shows functional deficient in the social imitation tasks. In current study, we hypothesize the structural connectivity in MNS would also be abnormal in ASD patients. By analyzing the cortical thickness and fiber tracks of specific MNS regions, we found that the bilateral pars opercularis has thinner cortical thickness and the commissural fiber between them also shows abnormal in ASD group. The preliminary result implies the structural deficits of MNS in ASD patients.

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