Abstract #1969
Regional increases of cortical thickness in untreated, first-episode major depressive disorder
Su Lu 1 , Lihua Qiu 2 , John A. Sweeney 3 , and Qiyong Gong 2
1
West China Hospital, Chengdu, Sichuan,
China,
2
West
China Hospital, Sichuan, China,
3
University
of Texas Southwestern, TX, United States
Most previous structural studies of major depressive
disorder (MDD) investigated volumetric changes in
chronic medicated patients. In the present study, we
investigate both the cortical thickness and surface area
changes in first-episode, treatment-nave, mid-life MDD.
By studying 46 first-episode, treatment-nave, mid-life
adult MDD patients and 46 matched controls, we firstly
observed greater rather than reduced cortical thickness
at early stage of MDD. These changes in first-episode,
treatment-nave, mid-life MDD patients may reflect an
active illness-related cortical change close to illness
onset, and thus may provide important new insight into
the early neurobiological manifestations of the
disorder.
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