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Abstract #1969

Regional increases of cortical thickness in untreated, first-episode major depressive disorder

Su Lu 1 , Lihua Qiu 2 , John A. Sweeney 3 , and Qiyong Gong 2

1 West China Hospital, Chengdu, Sichuan, China, 2 West China Hospital, Sichuan, China, 3 University of Texas Southwestern, TX, United States

Most previous structural studies of major depressive disorder (MDD) investigated volumetric changes in chronic medicated patients. In the present study, we investigate both the cortical thickness and surface area changes in first-episode, treatment-nave, mid-life MDD. By studying 46 first-episode, treatment-nave, mid-life adult MDD patients and 46 matched controls, we firstly observed greater rather than reduced cortical thickness at early stage of MDD. These changes in first-episode, treatment-nave, mid-life MDD patients may reflect an active illness-related cortical change close to illness onset, and thus may provide important new insight into the early neurobiological manifestations of the disorder.

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