Abstract #1962
7Li-MRS shows a higher lithium brain absorption in remission of bipolar disorder
Maria Concepcion Garcia Otaduy 1 , Marcus Vinicius Zanetti 2 , Rafael T. Sousa 2 , Wagner Farid Gattaz 2 , Claudia da Costa Leite 1 , and Rodrigo Machado-Vieira 2,3
1
Laboratory of Magnetic Resonance in
Neuroradiology, LIM 44, Institute and Department of
Radiology, University of So Paulo, So Paulo, SP,
Brazil,
2
Laboratory
of Neuroscience, LIM 27, Institute and Department of
Psychiatry, University of So Paulo, So Paulo, SP,
Brazil,
3
ETPB,
Mood and Anxiety Disorders Program, Department of Health
and Human Services, National Institute of Mental Health,
National Institutes of Health, Bethesda, MD, United
States
In this study we assessed by in vivo 7Li-MRS lithium
brain concentration in a group of patients with bipolar
disorder after 6 weeks of lithium therapy, in order to
test the hypothesis that patients presenting remission
of the disease have a different absorption of lithium in
the brain than non-remitted patients. Our results showed
a higher brain to serum lithium ratio in the group of
remitted patients when compared to patients with no
remission. For remitted patients lithium brain
concentration increased with lithium serum
concentration, while in the non-remitted group there was
no correlation between these measures.
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