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Abstract #1962

7Li-MRS shows a higher lithium brain absorption in remission of bipolar disorder

Maria Concepcion Garcia Otaduy 1 , Marcus Vinicius Zanetti 2 , Rafael T. Sousa 2 , Wagner Farid Gattaz 2 , Claudia da Costa Leite 1 , and Rodrigo Machado-Vieira 2,3

1 Laboratory of Magnetic Resonance in Neuroradiology, LIM 44, Institute and Department of Radiology, University of So Paulo, So Paulo, SP, Brazil, 2 Laboratory of Neuroscience, LIM 27, Institute and Department of Psychiatry, University of So Paulo, So Paulo, SP, Brazil, 3 ETPB, Mood and Anxiety Disorders Program, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

In this study we assessed by in vivo 7Li-MRS lithium brain concentration in a group of patients with bipolar disorder after 6 weeks of lithium therapy, in order to test the hypothesis that patients presenting remission of the disease have a different absorption of lithium in the brain than non-remitted patients. Our results showed a higher brain to serum lithium ratio in the group of remitted patients when compared to patients with no remission. For remitted patients lithium brain concentration increased with lithium serum concentration, while in the non-remitted group there was no correlation between these measures.

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