Meeting Banner
Abstract #1955

A whole brain approach of multimodal neuroimaging techniques for in vivo investigation of brain tissue changes in Alzheimer's Disease

Maria Marcella Lagan 1 , Niels Bergsland 1,2 , Mario Clerici 1,3 , Pietro Cecconi 1 , Giuseppe Baselli 2 , Raffaello Nemni 1,3 , and Francesca Baglio 1

1 Fondazione Don Carlo Gnocchi ONLUS, Milan, Milan, Italy, 2 Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Milan, Italy, 3 Physiopatholgy Department, Universit degli Studi di Milano, Milan, Italy

Recent MRI studies investigated the relationship between gray (GM) and white matter (WM) alterations in Alzheimers Disease, selecting areas known to be altered in AD and correlating their volumetric and DTI indices. We performed TBSS of 22 AD patients vs 23 healthy controls, mapped the results to the JHU-WM atlas, computed mean FA values of significant voxel corresponding to each atlas region and correlated them to GM volume, using VBM of the whole brain. A significant correlation between WM integrity and volume of near GM regions were obtained. The cause/effect interpretation of these results requires longitudinal multimodal MRI studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here